σ70 and PhoB activator
نویسندگان
چکیده
منابع مشابه
PhoB transcriptional activator binds hierarchically to pho box promoters.
The PhoR-PhoB phosphorelay is a bacterial two-component system that activates the transcription of several genes involved in phosphate uptake and assimilation. The response begins with the autophosphorylation of the sensor kinase PhoR, which activates the response regulator PhoB. Upon binding to the pho box DNA sequence, PhoB recruits the RNA polymerase and thereby activates the transcription o...
متن کاملAnatomy of Escherichia coli σ70 promoters
Information theory was used to build a promoter model that accounts for the -10, the -35 and the uncertainty of the gap between them on a common scale. Helical face assignment indicated that base -7, rather than -11, of the -10 may be flipping to initiate transcription. We found that the sequence conservation of sigma70 binding sites is 6.5 +/- 0.1 bits. Some promoters lack a -35 region, but ha...
متن کاملDraft Prokaryotic two - component systems and the OmpR / PhoB superfamily
23 In bacteria, two-component regulatory systems (TCSs) are the critical information-processing 24 pathways that link stimuli to specific adaptive responses. Signals perceived by membrane 25 sensors, which are generally histidine kinases (HKs), are transmitted by response regulators 26 (RRs) to allow cells to cope rapidly and effectively with environmental challenges. Over the 27 past few decad...
متن کاملPhoB Regulates the Survival of Bacteroides fragilis in Peritoneal Abscesses
In response to phosphate limitation, bacteria employ the Pho regulon, a specific regulatory network for phosphate acquisition. The two-component signal transduction system of PhoRB plays a crucial role in the induction of Pho regulon genes, leading to the adaptation to phosphate starvation. Herein, we identified the PhoRB system in Bacteroides fragilis, a commensal gut bacterium, and evaluated ...
متن کاملTwo transcription pause elements underlie a σ70-dependent pause cycle.
The movement of RNA polymerase (RNAP) during transcription elongation is modulated by DNA-encoded elements that cause the elongation complex to pause. One of the best-characterized pause sequences is a binding site for the σ(70) initiation factor that induces pausing at a site near lambdoid phage late-gene promoters. An essential component of this σ(70)-dependent pause is the elemental pause si...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Transcription
سال: 2012
ISSN: 2154-1264,2154-1272
DOI: 10.4161/trns.20444